Dissecting early pathogenesis of BRCA1/2-associated cancer for risk prediction and prevention
Principal Investigator: Leif Ellison | Affiliation: Massachusett's General Hospital
Research Keywords
Precancer biology, immunology
Research Questions
- What are the early changes in cells of BRCA carrier breast tissue?
- What are the BRCA cellular vulnerabilities?
- What are tissue-based markers for prevention approaches?
Specific Aims
- Aim 1:
- Aim 2:
- Aim 3:
Methods
- Singe cell RNA sequencing
- Organoid cultures